Lunes 18/05/20 índice de los constructores

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Moderna reports ‘positive’ data on early-stage coronavirus vaccine trial, shares surge 39%
PUBLISHED MON, MAY 18 20207:34 AM EDTUPDATED 7 MIN AGO
Berkeley Lovelace Jr.
@BERKELEYJR
Moderna’s closely watched early-stage human trial for a coronavirus vaccine produced Covid-19 antibodies in all 45 participants.
Each participant received a 25 microgram, 100 mcg or 250 mcg dose, with 15 people in each dose group.
At day 43, or two weeks following the second dose, levels of binding antibodies in the 25 mcg group were at the levels generally seen in blood samples from people who recovered from the disease
WATCH NOW
VIDEO01:02
Moderna reports early signs of progress during phase 1 Covid-19 vaccine trial
Moderna’s closely watched early-stage human trial for a coronavirus vaccine produced Covid-19 antibodies in all 45 participants, the biotech company announced Monday, sending the company’s shares surging more than 39% in premarket trading.

Each participant received a 25 microgram, 100 mcg or 250 mcg dose, with 15 people in each dose group. Study participants received two doses of the potential vaccine via intramuscular injection in the upper arm approximately 28 days apart. Data on a second dose was not available for the 250 mcg group, the company said.


At day 43, or two weeks following the second dose, levels of binding antibodies in the 25 mcg group were at the levels generally seen in blood samples from people who recovered from the disease, the company said. Antibodies in the 100 mcg had antibodies that “significantly exceeded levels” in recovered patients.

The vaccine also produced neutralizing antibodies against Covid-19 in at least eight participants, the company said. Experts have said neutralizing antibodies appear to be important in acquiring protection.

Four participants were assigned to receive a 25 microgram dose, while the other four received 100 mcg. Levels of neutralizing antibodies were at or above levels seen in blood samples, the company said. Data on neutralizing antibodies for the other participants were not yet available, Moderna said.

“These interim Phase 1 data, while early, demonstrate that vaccination with mRNA-1273 elicits an immune response of the magnitude caused by natural infection starting with a dose as low as 25 [micrograms],” Tal Zaks, the chief medical officer at Moderna, said in a statement.

“When combined with the success in preventing viral replication in the lungs of a pre-clinical challenge model at a dose that elicited similar levels of neutralizing antibodies, these data substantiate our belief that mRNA-1273 has the potential to prevent COVID-19 disease and advance our ability to select a dose for pivotal trials,” Zaks added.


WATCH NOW
VIDEO09:49
Moderna CEO on the promising preliminary results of early-stage Covid-19 study
Scientists hope the antibodies provide some degree of protection against getting Covid-19, but they can’t say that definitively yet since it hasn’t been studied and some patients appear to have been reinfected after recovering from the virus.

There are no formally approved treatments for Covid-19, which has killed at least 315,225 and sickened 4.7 million people worldwide since emerging from the Chinese city of Wuhan more than 4 months ago, according to data compiled by Johns Hopkins University. U.S. officials have said producing a vaccine to prevent Covid-19 would take 12 to 18 months at the earliest.

More than 100 vaccines are under development globally, according to the World Health Organization. At least eight vaccines are currently in human trials.

Moderna has been fast-tracking work with the National Institutes of Health, an agency within the Department of Health and Human Services, to develop a vaccine. Moderna is the first company to release data on a human trial testing a coronavirus vaccine.

The company said it expects to begin a phase 3 trial in July.

Earlier this month, Moderna announced that it was wrapping up phase one human trials on its potential vaccine with the U.S. government and is moving to start phase two trials that would include 600 participants. If the vaccine is found to be effective and safe to use, it could be ready for the market in early 2021, the company said.

The company said the vaccine was generally safe and well tolerated. To date, the most notable adverse events were seen in the 250-dose group where three participants developed “grade 3 systemic symptoms,” following the second dose, the company said.

The potential vaccine by Moderna contains genetic material called messenger RNA, or mRNA, that was produced in a lab. The mRNA is a genetic code that tells cells what to build — in this case, an antigen that may induce an immune response to the virus.

The phase 1 trial took place at the Kaiser Permanente Washington Health Research Institute in Seattle, Washington. It tested the vaccine on 45 males and non-pregnant females between the ages of 18 and 55.

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https://www.wsj.com/articles/moderna-sa ... 15?mod=mhp

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Gilead sign licensing deal for Remdesivir with three Indian companies

India’s Jubilant Life SciencesNSE 5.00 %, Hetero and Cipla have signed licensing deal with US-based Gilead Sciences for manufacturing remdesivir, a drug which has been identified as a potential therapy for Covid-19. The licensing agreement is for India and 127 other low, middle income and upper middle income countries where the Noida-based company will market the drug.

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https://www.wsj.com/articles/teslas-pro ... 02?mod=mhp

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Betting against the U.S. economy and consumer is a loser’s game’ — why one strategist sees Dow 40,000 on the horizo

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